Hemithoracic Arc Radiotherapy Post Pleural Decortication

Cairo University (CU)

Status: Enrolling

Conditions: Malignant Pleural Mesothelioma

Treatments: Radiation: hemithoracic Volumetric Arc Radiotherapy post Pleural decortication

Study type: Interventional

Funder types: Other

Identifiers

NCT06910449

RO2405-291-047-193

Details and patient eligibility

About

Malignant Pleural Mesothelioma is an aggressive and refractory disease , the most aggressive treatment plan offered to these patients include trimodalitiy approach with chemotherapy as the mainstay of treatment . the rationale of post operative Radiotherapy is to sterilize the post operative volume to reduce local failure meanwhile minimizing toxicities in this trial we are going to assess the safety and efficacy of Radiotherapy in Mesothelioma patients poat Pleural decortication

Full description

This study will include malignant Pleural Mesothelioma patients treated by trimodalitiy approach starting with neoadjuvant chemotherapy followed by surgery in the form of Pleural decortication then all patients will receive post operative hemithoracic radiation

Enrollment: 45 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Evidence of metastatic disease.
• Underwent Pleural decortication.
• Able to provide informed consent.

Exclusion criteria

• Poor pulmonary function tests.
• Recurrent or palliative cases.
• Inability to attend full course of Radiotherapy or follow up visits.

Trial design

Primary purpose: Other

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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45 participants in 1 patient group

single arm receiving postoperative radiotherapy

Experimental group

Description:

single arm receiving post operative Radiotherapy to the hemithorax

Treatment:

Radiation: hemithoracic Volumetric Arc Radiotherapy post Pleural decortication