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Hemodialysis Frequency and the Calcification Propensity of Serum (Intensified HD)

I

Insel Gruppe AG, University Hospital Bern

Status

Completed

Conditions

Hemodialysis
Anuria

Treatments

Procedure: Short daily dialysis for 2 weeks

Study type

Interventional

Funder types

Other
Industry

Identifiers

Details and patient eligibility

About

The aim of this clinical research project is to test the hypothesis that daily dialysis has favorable effects on the calcification propensity of human serum, when determined by the investigators' newly developed in vitro serum test. The investigators' hypothesis is that shorter interdialytic intervals will result in an improved calcification propensity of serum. The determination of serum calcification has the potential to become a novel measure of dialysis quality in the future.

Full description

Background

The serum calcification test has been established and validated by A. Pasch and coworkers, the expertise to perform the necessary statistical analyses is present in the investigator's department, all patient-related procedures necessary for this project are routinely performed in the investigator's department.

Objective

Does short daily hemodialysis strengthen the calcification-inhibitory forces inherent in hemodialysis patient sera, when compared to conventional three-times weekly hemodialysis?

Methods

Serum calcification test

Enrollment

17 patients

Sex

All

Ages

18+ years old

Volunteers

No Healthy Volunteers

Inclusion and exclusion criteria

Inclusion Criteria:

  • Chronic hemodialysis >3 months
  • Anuria (<100ml urine per day)
  • Written informed consent

Exclusion Criteria

  • Citrate dialysis
  • Significant fistula recirculation (>15%)
  • Infection

Trial design

Primary purpose

Treatment

Allocation

Non-Randomized

Interventional model

Crossover Assignment

Masking

None (Open label)

17 participants in 1 patient group

All study participants
Experimental group
Description:
Short daily dialysis for 2 weeks
Treatment:
Procedure: Short daily dialysis for 2 weeks

Trial contacts and locations

1

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Data sourced from clinicaltrials.gov

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