Hemodialysis-Induced Renal Perfusion Decline: Unraveling the Pathophysiological Mechanisms Linking Intradialytic Circulatory Stress to Residual Renal Function Loss (HD-RPD)

Yuanjun Yang

Status: Active, not recruiting

Conditions: End-Stage Renal Disease Requiring Haemodialysis

Treatments: Diagnostic Test: CEUS examinations

Study type: Observational

Funder types: Other

Identifiers

NCT07003828

S2024-294-01

Details and patient eligibility

About

Residual renal function (RRF) plays a critical role in quality of life and survival in hemodialysis (HD) patients but characteristically declines after the initiation of HD. Owing to incomplete understanding of the pathophysiology underlying RRF decline, protective strategies remain limited. The aim of this study was to characterize the changes in renal perfusion in incident HD patients with preserved RRF during dialysis sessions and to provide new strategies for RRF preservation.

Enrollment: 30 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• (1) adult patients with end-stage renal disease (ESRD) within 3 months of commencing HD; (2) preserved RRF defined as urinary output >500 mL/24 h or eGFR ≥3 mL/min/1.73 m²

Exclusion criteria

• (1) known allergy to sulfur hexafluoride microbubbles (SonoVue®) microbubbles; (2) vascular access dysfunction; (3) combined peritoneal dialysis; (4)severe cardiopulmonary disease; (5) active infection or malignancy; (6) communicable diseases; (7) pregnancy or breastfeeding; (8) participation in other clinical trials.

Trial design

30 participants in 1 patient group

adult patients with end-stage renal disease (ESRD) within 3 months of commencing HD

Treatment:

Diagnostic Test: CEUS examinations