Hemodynamic and Salivary Responses of 12 Weeks of Training With Different Anti-hypertensive

Federal University of Uberlandia

Status: Terminated

Conditions: Hypertension; Menopause

Treatments: Other: Combined exercise

Study type: Interventional

Funder types: Other

Identifiers

NCT03529838

71285317.4.0000.5152

Details and patient eligibility

About

Different classes of antihypertensives may have different responses when associated with exercise. Thus, this study aims to compare the responses of the association of 12 weeks of aerobic exercise and weightlifting with different classes of medications in 45 postmenopausal hypertensive women.

Full description

Cardiovascular diseases are the leading causes of death and postmenopausal women. Physical exercise, in turn, is a strategy to reduce cardiovascular stress, by decreasing the blood pressure (BP) at rest and several risk factors associated with sedentary lifestyle, thus improving the quality and life expectancy of these women. However, different classes of antihypertensives may have different responses when associated with exercise. Thus, this study aims to compare the responses of the association of 12 weeks of aerobic exercise and weightlifting with different classes of medications in 45 postmenopausal hypertensive women. The volunteers will do cardiovascular and biochemistry evaluations before and after the intervention.

Enrollment: 30 patients

Sex: Female

Ages: 50 to 70 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Women aged between 50 and 70 years;
• Be in the postmenopausal phase;
• Be able to practice physical exercise on treadmill and bodybuilding,
• Receive a release certificate for exercise practice;
• Do not present physical problems or cardiovascular complications that prevent the performance of physical exercises;
• In the case of hypertensives: present stage 1 hypertension, according to the guidelines of the Brazilian Society of Hypertension (2010);
• In the case of hypertensive patients, undergo drug treatment with β-blockers or Angiotensin receptor blockers.

Exclusion criteria

• Present history of stroke or acute myocardial infarction;
• Smokers;
• Present diagnosis of Diabetes Mellitus or renal pathologies;
• Use of antihypertensive drugs from classes that were not selected for this project;
• Make use of hormonal therapies;
• Being uncompensated hypertensive.

Trial design

Primary purpose: Prevention

Allocation: Non-Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

---

30 participants in 3 patient groups, including a placebo group

No medication

Placebo Comparator group

Description:

Group of pre-hypertensive women with no medication who practiced 12 weeks of training with Combined Exercise Training, non-obese, nonsmokers and with no characteristics that prevented them from performing the activities. In addition this group could not modify the dose or type of the medicine and should be using the same medicine and dose for at least 6 months

Treatment:

Other: Combined exercise

Angiotensin receptor blockers

Active Comparator group

Description:

Group of hypertensive women taking Angiotensin receptor blockers who practiced 12 weeks of training with Combined Exercise Training, non-obese, nonsmokers and with no characteristics that prevented them from performing the activities. In addition this group could not modify the dose or type of the medicine and should be using the same medicine and dose for at least 6 months

Treatment:

Other: Combined exercise

Beta blockers

Active Comparator group

Description:

Group of hypertensive women taking Beta blockers who practiced 12 weeks of training with Combined Exercise Training, non-obese, nonsmokers and with no characteristics that prevented them from performing the activities. In addition this group could not modify the dose or type of the medicine and should be using the same medicine and dose for at least 6 months

Treatment:

Other: Combined exercise