Hemodynamic Changes After Anesthesia With Propofol: Study of Biomarkers

Conselho Nacional de Desenvolvimento Científico e Tecnológico

Status: Completed

Conditions: Hemodynamic Responses to Propofol

Study type: Observational

Funder types: Other

Identifiers

NCT02442232

CNPq (Other Grant/Funding Number)

Details and patient eligibility

About

The purpose of this study is to evaluate biomarkers affecting the hemodynamic responses to propofol. Particularly, the investigators will assess the effects of polymorphisms in NOS3 and PRKCA genes on hemodynamic responses to propofol and the effects of these polymorphisms on biomarkers related to nitric oxide after propofol anesthesia. In addition, the investigators will evaluate the effects of propofol anesthesia on biomarkers related to nitric oxide in hypertensive patients chronically treated with angiotensin-converting enzyme inhibitors.

Enrollment: 65 patients

Sex: All

Ages: 40 to 80 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• ASA I or II
• BMI lower 30 kg/m2

Exclusion criteria

• Severe hypertension
• Previous stroke
• Previous infarction
• Uncontrolled respiratory, renal, hepatic and hematological diseases.

Trial design

65 participants in 3 patient groups

Normotensive

Hypertensive taking ACEi

Hypertensive not taking ACEi