Hemodynamic Characteristics of Patients With SARS-CoV-2 (PiCCOVID)

Bicetre Hospital

Status: Completed

Conditions: Acute Circulatory Failure; COVID-19; Shock; Acute Respiratory Distress Syndrome; SARS-CoV-2; Fluid Overload; Left Ventricular Dysfunction; Coronavirus

Treatments: Device: Echocardiography; Device: Transpulmonary thermodilution

Study type: Observational

Funder types: Other

Identifiers

NCT04337983

2020-A00793-36

Details and patient eligibility

About

The outbreak of coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been declared a public health emergency of international concern. Hospitalized COVID-19-positive patients requiring ICU care is increasing along with the course of epidemic. A large number of these patients developed acute respiratory distress syndrome (ARDS) according to current data. However, the related hemodynamic characteristic has so far been rarely described.

Full description

The outbreak of COVID-19 is a worldwide concern. To our knowledge, the details of the hemodynamic characteristics of COVID-19 patients have not yet been well described. Besides, the cardiac injury was reported in about 7-17% of hospitalized patients with COVID-19 in previous Chinese publications and is much more common in patients admitted to ICU and non-survivors. However, no systematic assessment, including echocardiography evaluating the left ventricular function of these patients has been declared. In addition, extravascular lung water (EVLW) and pulmonary capillary permeability are two hall markers in ARDS patient's management, and transpulmonary thermodilution is a validated method to provide these values at the bedside. However, no study has reported the characteristic profile of these variables during ARDS caused by SARS-Cov2. A better knowledge of these characteristics would also be helpful in guiding their management.

Enrollment: 60 patients

Sex: All

Volunteers: No Healthy Volunteers

Inclusion criteria

• Confirmed or suspected SARS-Cov2 cases
• Patients admitted to ICU, defined as a unit in which patients can receive vasopressors.
• Monitored by a transpulmonary thermodilution system (PiCCO2 (Pulsion Medical Systems, Feldkirchen, Germany) or EV1000 (Edwards Lifesciences, Irvine, United States of America).

Exclusion criteria

• SARS Cov-2 Negative
• Refusal to participate in the study