Hemodynamic Effect of Nasal High-flow in Patients Suspected or Followed for a Precapillary Pulmonary Hypertension (HighFlowHD)

ADIR Association

Status: Enrolling

Conditions: Pulmonary Hypertension

Treatments: Device: Nasal high-flow

Study type: Interventional

Funder types: Other

Identifiers

NCT06079151

HighFlowHD

Details and patient eligibility

About

In this study, the investigators aim to describe the hemodynamic consequences of nasal high-flow measured during right heart catheterization and echocardiography. The research hypothesis is that nasal high-flow would increase cardiac output in patients with pulmonary hypertension. The concomitant echocardiography will allow to describe its sensibility to detect cardiovascular consequences of nasal high-flow.

Enrollment: 20 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• patient addressed for right heart catheterization for pulmonary hypertension suspicion or follow-up.

Exclusion criteria

• necessity of FiO2 >21% during right heart catheterization
• intracardiac shunt
• grade 4 tricuspid insufficiency
• complete arrhythmia due to atrial fibrillation
• Pregnant or breastfeeding women or women of childbearing age without an effective method of contraception
• protected adult patient (tutorship or curatorship)
• patient deprived of liberty by court or administrative decision
• refusal of patient participation or consent
• patient for whom the measurement of pulmonary arterial pressures during right heart catheterization is impossible
• patient for whom, during the etiological assessment of pulmonary hypertension, the diagnosis of precapillary pulmonary hypertension cannot be confirmed and classified in groups 1, 3 or 4.

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: None (Open label)

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20 participants in 2 patient groups

Nasal high-flow 30 L/min and then 50 L/min

Experimental group

Description:

The patient will be placed successively under nasal high-flow 30 L/min during 20 min and then 50 L/min during 20 min.

Treatment:

Device: Nasal high-flow

Nasal high-flow 50 L/min and then 30 L/min

Experimental group

Description:

The patient will be placed successively under nasal high-flow 50 L/min during 20 min and then 30 L/min during 20 min.

Treatment:

Device: Nasal high-flow