Hemodynamic Effects of Cold Versus Warm Fluid Bolus

Karolinska Institute

Status: Completed

Conditions: Hypovolemia; Temperature Change, Body

Treatments: Drug: Ringer's Acetate (cold); Drug: Ringer's Acetate (warm)

Study type: Interventional

Funder types: Other

Identifiers

NCT03209271

EPN 2016/986-31/1

Details and patient eligibility

About

Fluid boluses are often administered with the aim of improving tissue perfusion in critically ill patients. It is unclear whether the temperature of the fluid has an impact on the hemodynamic response. The aim of this study is to describe the hemodynamic effects of a fluid bolus with two different temperatures.

Full description

A randomized, controlled, cross-over study in 21 healthy volunteers. The participants will receive a fluid bolus of 500 ml Ringer's Acetate at either 22°C or 38°C over 15 minutes in a randomized order. Non-invasive measures will be made of cardiac index, mean arterial pressure, systolic blood pressure, diastolic blood pressure, heart and pulse rate, saturation and temperature. Hemodynamic measure will be made using the Clearsight® system. Measurements will be made during 120 minutes. The second session will take place at least one day later, and the participant will then receive the other fluid temperature.

Enrollment: 21 patients

Sex: All

Ages: 18+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Volunteers 18 years or older Previously healthy

Exclusion criteria

• American Society of Anesthesiologists classification 2 or above.
• Known pregnancy

Trial design

Primary purpose: Basic Science

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: None (Open label)

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21 participants in 2 patient groups

Body temperature fluid

Experimental group

Description:

500ml Ringers Acetate infused over 15 minutes warmed to 38°C

Treatment:

Drug: Ringer's Acetate (warm)

Room temperature fluid

Active Comparator group

Description:

500ml Ringers Acetate infused over 15 minutes cooled to 22°C

Treatment:

Drug: Ringer's Acetate (cold)