Hemodynamic Effects of Spironolactone in Patients With Heart Failure

University of Toledo Health Science Campus

Status: Completed

Conditions: Congestive Heart Failure

Treatments: Drug: Spironolactone

Study type: Interventional

Funder types: Other

Identifiers

NCT00860340

xMUO-02

Details and patient eligibility

About

To determine if the beneficial effect of spironolactone in patients with congestive heart failure is in part due to its intrinsic inotropic action.

Randomized, two group placebo controlled, single blind study.

Enrollment: 18 patients

Sex: All

Ages: 21 to 80 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• CHF
• 21 - 80 years
• Serum creatinine < 2 mg/dL
• Serum potassium 2.7 - 4.5 mg/dL measured within past 4 weeks

Exclusion criteria

• Less than 21 years
• Pregnancy

Trial design

Primary purpose: Treatment

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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18 participants in 1 patient group

1

Experimental group

Description:

Study patient will take 100mg tablet of Spironolactone

Treatment:

Drug: Spironolactone