Hemodynamic Effects of Stored Blood Transfusion in Intensive Care Patients

Medical University of Vienna

Status and phase: Terminated; Phase 4

Conditions: Pulmonary Hypertension

Treatments: Biological: Blood transfusion

Study type: Interventional

Funder types: Other

Identifiers

NCT02050230

BASG 2013-002316-27

2013-002316-27 (EudraCT Number)

Details and patient eligibility

About

Transfusion of stored blood has been associated with increased pulmonary vascular resistance in lambs. The investigators hypothesize that transfusion of one unit of red blood cells stored under standard conditions in intensive care patients will increase pulmonary arterial pressure and pulmonary vascular resistance to a greater extent than will one unit of fresh red blood cells.

Enrollment: 11 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

1. The patient has a pulmonary artery catheter in place
2. Transfusion of 1 unit of packed red blood cells indicated for standard intensive care therapy
3. The patient has an arterial catheter

Exclusion criteria

1. Age < 18 years
2. Clinical prediction that the patient will not survive at least 48 hours
3. Acute bleeding: > 2 units of packed red blood cells/hour
4. Vasopressor use: noradrenalin > 0.2 μg/kg/min or any use of adrenalin within 6 hours of inclusion into the study
5. Therapy with inhaled NO, inhaled prostacyclin, or phosphodiesterase-5-inhibitors
6. Sepsis

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Triple Blind

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11 participants in 2 patient groups

Fresh blood transfusion

Active Comparator group

Description:

One unit of blood stored for less than 14 days

Treatment:

Biological: Blood transfusion

Standard issue blood transfusion

Experimental group

Description:

One unit of blood stored under standard conditions

Treatment:

Biological: Blood transfusion