Hemodynamic Effects on Cerebral Autoregulation in Acute Stroke

Henry Ford Health

Status: Completed

Conditions: Ischemic Stroke

Study type: Observational

Funder types: Other

Identifiers

NCT02056821

A20030

Details and patient eligibility

About

This study investigates if there are hemodynamic alterations in acute stroke that predispose patients to impaired perfusion and regulation of cerebral blood flow. To test this, we will target recruitment of acute ischemic stroke patients who present to the ED within 12 hours of symptoms onset. Enrolled subjects will receive continuous noninvasive hemodynamic monitoring contemporaneous with measurements of cerebral blood flow velocities and cerebral oximetry.

Enrollment: 88 patients

Sex: All

Ages: 18 to 90 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Suspected ischemic stroke within 12 hours of symptom onset
• NIHSS ≥ 4
• Age 18 to 90 years

Exclusion criteria

• Baseline modified Rankin Scale > 3
• Pregnancy
• Intracranial hemorrhage on head CT
• Mechanical ventilation prior to enrollment
• Inadequate temporal windows for TCD analysis