Hemodynamic Impact of the Administration of PAracetamol in Patients Hospitalized in the Intensive Resuscitation Medicine Department [PAREA]

Centre Hospitalier Universitaire de Nice

Status: Not yet enrolling

Conditions: Intensive Care Unit Syndrome

Treatments: Drug: paracetamol administration

Study type: Interventional

Funder types: Other

Identifiers

NCT06430697

22-AOI-13

Details and patient eligibility

About

Paracetamol is commonly used in case of pain or fever. Few previously clinical studies has highlighted an arterial hypotension linked to intravenous administration of paracetamol. Currently, fewer data are available on the link of intravenous administration of paracetamol and effects on arterial tension. The aim of this study is to describe the frequency of occurrence of significative arterial hypotension within one hour following intravenous or per os administration of paracetamol . Other factors who can be associated to occurence of significative arterial hypotension will be also observe (for example age, weight, pain, vasopressor dosage or sedative...)

Enrollment: 200 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion and exclusion criteria

Inclusion Criteria:

Inclusion:

• 18 years of age or older
• Patient with arterial catheter
• Indication of paracetamol's administration by the patient's attending practitioner.
• No opposition to patient or support person participation in the study if the patient is unable to participate

ExclusionCriteria:

• No Social Security Patient
• Pregnant or nursing patient.
• Patient with a legal protection measure
• Hypersensitivity and/or allergy to paracetamol.
• Contraindication to the use of paracetamol.
• Patient opposition to health data collection.

Trial design

Primary purpose: Prevention

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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200 participants in 1 patient group

Treatment with paracetamol

Experimental group

Treatment:

Drug: paracetamol administration