Hemodynamic Monitoring in Hepatopancreaticobiliary (HPB) Surgery

Wake Forest University (WFU)

Status: Completed

Conditions: Cancer

Treatments: Device: Minimally invasive hemodynamic monitoring

Study type: Observational

Funder types: Other

Identifiers

NCT03612687

03-14-03E

Details and patient eligibility

About

This is a pilot study with the primary objective to validate the use of advanced minimally invasive hemodynamic monitoring with the PreSep™ Central Venous Oximetry Catheter, the Vigileo™ monitor, and FloTrac™ sensor for perioperative fluid management in Hepatobiliary and Pancreas Surgery. All of these devices and monitors are FDA approved devices and routinely used in the perioperative setting for these cases.

Full description

Surgical procedures involving the liver and pancreas are complex and involve paying close attention to hemodynamics to keep the patient stable through the duration of the case. Volume overload in liver and pancreas surgery leads to more intraoperative blood loss and rapid volume shifts make the patient unstable and more difficult to manage. Traditional methods of invasive monitoring to determine cardiac output and stroke volume include the placement of a pulmonary artery catheter and an arterial line. With the addition of the FloTrac™ Sensor to the arterial line and the Vigileo™ monitor; a pulmonary artery catheter would be no longer required. The minimally invasive cardiac output monitor connected to the central venous catheter will generate detailed information of cardiac function and fluid status and thereby help monitor and manage the hemodynamics of the patient intraoperatively. The information obtained from the Vigileo™ will be compared to the regular data normally available in patients undergoing hepatobiliary surgery to determine the advantages of using the system to aid in fluid management of the patient.

Enrollment: 20 patients

Sex: All

Ages: 18+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

1. Adult male and female patients admitted to Carolinas Medical Center (CMC) with the need for the following surgical procedures: liver resection, distal pancreatectomy and splenectomy, and pancreaticoduodenectomy.

Exclusion criteria

1. Indication for emergency surgery, including pancreatic debridement in an acute setting; ruptured hepatic adenomas/hepatocellular carcinomas
2. Suspected inability to comply with trial procedures or understand consent
3. Employee at the investigational center, relative or spouse of the investigators
4. Patients incarcerated at the time of surgery
5. Females who are pregnant or breastfeeding
6. Planned use of Cell Saver during surgical procedure

Trial design

20 participants in 4 patient groups

Laparoscopic Liver Surgery

Description:

Laparoscopic Liver Surgical Procedures with minimally invasive hemodynamic monitoring

Treatment:

Device: Minimally invasive hemodynamic monitoring

Laparoscopic Pancreas Surgery

Description:

Laparoscopic Pancreas Surgical Procedures with minimally invasive hemodynamic monitoring

Treatment:

Device: Minimally invasive hemodynamic monitoring

Open Liver Surgery

Description:

Open Liver Surgical Procedures with minimally invasive hemodynamic monitoring

Treatment:

Device: Minimally invasive hemodynamic monitoring

Open Pancreas Surgery

Description:

Open Pancreas Surgical Procedures with minimally invasive hemodynamic monitoring

Treatment:

Device: Minimally invasive hemodynamic monitoring