Hemodynamic Parameters in Euthyroid Patients With Thyroid Nodules

Yaroslavl State Medical Academy

Status: Terminated

Conditions: Thyroid Nodules

Study type: Observational

Funder types: Other

Identifiers

NCT00507897

ESheverdova-1

Details and patient eligibility

About

The purpose of this study is to determine the relationship of hemodynamic parameters with the level of thyroid hormones and the histological structure of thyroid nodules in euthyroid patients.

Full description

As opposed to widely investigated condition of cardiovascular system in patients with functional disorders of thyroid gland, the relationship between thyroid hormones and hemodynamic parameters in euthyroid patients remains not enough clear.

We detect the parameters of blood pressure and thyroid hormones in euthyroid patients with thyroid nodules directly before planned operation on the thyroid gland.

As the study is carries out directly before operation, that assumes presence of preoperative stress in patients, activity of the sympatho - adrenal system is estimated in addition.

On the one hand, the design of our research will allow to estimate relationship of thyroid hormones with the parameters of blood pressure in conditions of euthyroidism, on the other hand - to investigate features of blood pressure in patients with thyroid nodules.

The research of the patients in the preoperative period will enable to select the group of patients without pathology of cardiovascular system whose increased blood pressure is connected with preoperative stress, that in turn will allow to exclude influence of the pathology of the cardiovascular system on studied correlation.

Enrollment: 100 estimated patients

Sex: All

Volunteers: No Healthy Volunteers

Inclusion criteria

• Euthyroid patients with thyroid nodules before operation on the thyroid gland

Exclusion criteria

• Hyperthyroidism
• Hypothyroidism

Trial design

100 participants in 4 patient groups

A

Description:

Cohort: Patients with normal blood pressure scheduled to have thyroid nodules surgically removed

A1

Description:

Patients from group A not receiving any drugs and who lack other pathology, gender and age matched group B1

B

Description:

Cohort: Patients with increased blood pressure scheduled to have thyroid nodules surgically removed

B1

Description:

Patients from group B not receiving any drugs and who lack other pathology, gender and age matched group A1