Hemodynamic Response to Intubation

Ufuk University

Status and phase: Unknown; Phase 4

Conditions: Intubation

Treatments: Drug: Esmolol; Drug: Placebo; Drug: Dexmedetomidine

Study type: Interventional

Funder types: Other

Identifiers

NCT02844894

RespToIntubation

Details and patient eligibility

About

This study investigates the effects of dexmedetomidine and esmolol given intravenously before intubation on sympathetic response caused by intubation itself. Half the patients will recevice dexmedetomidine and the other half will receive dexmedetomidine. Ischemia modified albumine levels will be measured

Enrollment: 60 estimated patients

Sex: All

Ages: 18 to 65 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patients undergoing elective surgery under general anesthesia

Exclusion criteria

• Patient refusal
• Morbid obesity (BMI>30)
• Advanced systemic disease
• Hypoalbumiemia
• beta-blocker usage
• Anticipated difficult ventilation and/or intubation

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Triple Blind

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60 participants in 3 patient groups, including a placebo group

dexmedetomidine

Experimental group

Description:

0.5 mcg/kg dexmedetomidine in 20 ml normal saline will be infused in 5 minutes before intubation

Treatment:

Drug: Dexmedetomidine

Esmolol

Experimental group

Description:

0.5 mg/kg esmolol in 20 ml normal saline will be infused in 5 minutes before intubation

Treatment:

Drug: Esmolol

Placebo

Placebo Comparator group

Description:

20 ml normal saline infused in 5 minutes before intubation

Treatment:

Drug: Placebo