Hemodynamics for Equi-MAC Anesthesia

Kangbuk Samsung Hospital

Status

Completed

Conditions

Anesthesia

Treatments

Drug: Desflurane

Drug: Sevoflurane

Study type

Interventional

Funder types

Other

Identifiers

NCT03570164

2018-05-019

Details and patient eligibility

About

The aim of this study is to compare the peripheral perfusion index values produced by equi-MAC of sevoflurane and desflurane in patients undergoing single-agent inhalation anesthesia.

Full description

Ether derivative anesthetics, including sevoflurane and desflurane, have direct activity on vascular tissue and both are vasodilators. However, there has been no direct comparison of vasodilative effect between sevoflurane and desflurane in vivo in humans. Peripheral perfusion index derived from photoplethysmographic waveform reflects peripheral vasomotor tone. Therefore, the purpose of this study is to compare the peripheral perfusion index values produced by sevoflurane and desflurane at equipotent concentration in patients undergoing single-agent inhalation anesthesia.

Enrollment

70 patients

Sex

All

Ages

19 to 65 years old

Volunteers

No Healthy Volunteers

Inclusion criteria

patients aged between 19 and 65 yr
patients with American Society of Anesthesiologists physical status classification I or II
patients scheduled for elective arthroscopic knee surgery under general anesthesia
patients obtaining written informed consent

Exclusion criteria

patients with a history of any disease associated with the autonomic nervous system
patients receiving any medication affecting the sympathetic or parasympathetic nervous systems
patients with cardiac arrhythmia, diabetes mellitus, and alcohol or drug abuse
pregnant women