Hemofilter Life Span, ECLS And/or CRRT

Medical University of South Carolina (MUSC)

Status: Completed

Conditions: Acute Injury of Kidney; Renal Failure; Kidney Diseases; Neonatal Renal Disorder (Disorder); Renal Insufficiency

Study type: Observational

Funder types: Other; Industry

Identifiers

NCT04193865

00094177

Details and patient eligibility

About

The goal of this project to better understand the immune-modulatory effects of continuous renal replacement therapy (CRRT) in neonatal and pediatric patients, particularly those receiving extracorporeal life support (ECLS). Little is known about the effects of CRRT in this particular population and improved knowledge will be useful clinically and may lead to novel therapeutic approaches and improved outcomes for these critically ill patients.

Full description

Via collection of serum and ultrafiltrate samples, the invesitgators will examine how hemofilter lifespan alters the filtration of pro- and anti-inflammatory cytokines.

Enrollment: 10 patients

Sex: All

Ages: Under 17 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Neonatal or pediatric patients receiving ECLS (>2 kilograms and >34 weeks gestation)
• CRRT utilized during ECLS course
• For the secondary endpoints comparing CRRT-mediated cytokine filtration in patients receiving ECLS with concurrent CRRT to patients receiving CRRT alone (no ECLS), the investigators will also enroll neonatal and pediatric patients receiving CRRT alone (no ECLS). Patients will be eligible for entry into this study if they meet all of the following criteria:
• Neonatal or pediatric patients receiving CRRT

Exclusion criteria

-Those patients with inability or unwillingness of legal guardian/representative to give informed consent

Trial design

10 participants in 2 patient groups

Extracorporeal Life Support with Renal Replacement Therapy

Description:

This cohort will include all subjects receiving extracorporeal life support with concurrent continuous renal replacement therapy. Two blood samples and one ultrafiltration sample will be obtained for the study protocol twice per day (every 12 hours) for the duration of each participants's CRRT course.

Renal Replacement Therapy

Description:

This cohort will include all subjects receiving continuous renal replacement therapy (no extracorporeal life support). Two blood samples and one ultrafiltration sample will be obtained for the study protocol twice per day (every 12 hours) for the duration of each patient's CRRT course.