Heparin-Binding Protein and Heparins (HepHep)

Halla Halldorsdottir

Status: Completed

Conditions: Cardiovascular Diseases; Vascular Disease, Peripheral; Thromboprophylaxis

Treatments: Diagnostic Test: Blood samples for Heparin-binding protein measurement

Study type: Observational

Funder types: Other

Identifiers

NCT04146493

4-2957/2017

Details and patient eligibility

About

Heparin-Binding protein is a protein from primary and secretory granluae of white blood cells. It is released when white blood cells become activated and has been advocated as a biomarker for sepsis. The aim of this study is to find out if Heparins in clinical doses can change the level of Heparin-binding protein in plasma.

Full description

Blood samples are taken from patients before and after Heparins in clinical doses. The effects of heparins on Heparin-binding protein concentration in plasma is measured. This is a small observational study.

Enrollment: 60 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Planned endovascular treatment of aortic aneurysm or peripheral vascular surgery where unfractionated heparin in >3000 units are given perioperatively
• Planned subcutaneous low molecular weight heparin as a thromboprophylactic treatment after major surgery or on Intensive Care treated patients.
• Planned open heart surgery with cardiopulmonary bypass.

Exclusion criteria

• Under 18 years
• Unable to get informed consent from patient or relative

Trial design

60 participants in 3 patient groups

Vascular surgery group

Description:

Patients which are given unfractionated heparin during their vascular surgery.

Treatment:

Diagnostic Test: Blood samples for Heparin-binding protein measurement

Thromboprophylaxis group

Description:

Patients which are given low molecular heparins as a thrombosprofylax after major surgery

Treatment:

Diagnostic Test: Blood samples for Heparin-binding protein measurement

Cardiothoracic surgery

Description:

Patients which are given high dose unfractionated heparin during their open heart surgey

Treatment:

Diagnostic Test: Blood samples for Heparin-binding protein measurement