ClinicalTrials.Veeva

Menu

Hepatectomy Versus Hepatectomy With Lymphadenectomy in Hepatocellular Carcinoma

Sun Yat-sen University logo

Sun Yat-sen University

Status

Completed

Conditions

Hepatocellular Carcinoma

Treatments

Procedure: hepatectomy combined with lymphadenectomy
Procedure: hepatectomy alone

Study type

Interventional

Funder types

Other

Identifiers

NCT02031952
Rvrl2005

Details and patient eligibility

About

The preventive lymphadenectomy is not performed routinely for hepatocellular carcinoma (HCC) patients in clinical practice. While many patients suffered the recurrence without the evidence of portal or hepatic vascular invasion or multiple loci, it lead to reconsider the value of preventive resection of regional lymph node for those patients. Recently, more and more studies had found the incidence of lymph node metastasis was higher in autopsy specimen than those in operable patients.

This project is a prospective randomized controlled trial, planning to compare hepatectomy with hepatectomy combined lymphadenectomy regarding of the safety and efficacy in HCC patients, to reach a further understanding of the role of lymphadenectomy.

Enrollment

87 patients

Sex

All

Ages

18 to 65 years old

Volunteers

No Healthy Volunteers

Inclusion criteria

  • age 18 to 65 years;
  • Eastern Cooperative Oncology Group (ECOG) Performance Status is grade 0 or 1;
  • good liver function with Pugh-Child Class A or B;
  • indocyanine green retention at 15 minutes (ICG-R15) <15%;
  • without severe cirrhosis;
  • the diameter of tumor is equal to or more than 3 cm;
  • the liver resection could be assessed R0 (the define of R0 resection will be explained in the section of Surgical procedures);
  • absence of extrahepatic metastasis.

Exclusion criteria

  • the diameter of tumor is less than 3 cm;
  • palliative resection of tumor;
  • with the history of hepatic encephalopathy, ascites, and variceal bleeding;
  • with severe hepatic cirrhosis;
  • tumor rupture;
  • with the history of upper abdominal surgery, it is tough to remove the regional lymph nodes; or it is unable to be resected when multiple lymph nodes mixed and fixed.

Trial design

Primary purpose

Treatment

Allocation

Randomized

Interventional model

Parallel Assignment

Masking

Double Blind

87 participants in 2 patient groups

hepatectomy combined lymphadenectomy
Experimental group
Description:
hepatectomy combined lymphadenectomy
Treatment:
Procedure: hepatectomy combined with lymphadenectomy
hepatectomy
Active Comparator group
Description:
hepatectomy alone
Treatment:
Procedure: hepatectomy alone

Trial contacts and locations

1

Loading...

Data sourced from clinicaltrials.gov

Clinical trials

Find clinical trialsTrials by location
© Copyright 2024 Veeva Systems