Hepatectomy With or Without the Thoraco-abdominal Approach

University of Milan

Status: Completed

Conditions: Liver Resection; Surgery; Hepatectomy; Liver Tumors

Treatments: Procedure: Hepatectomy

Study type: Observational

Funder types: Other

Identifiers

NCT03171428

ThoraxForLiver

Details and patient eligibility

About

The performance of hepatectomy for liver tumors using the thoraco-abdominal approach (TAA) versus the abdominal approach (AA) is still debated.

The aim of the study is the analysis of the perioperative outcome of patients operated with or without the TAA for liver tumors.

Full description

The prospectively maintained database was queried. A 1:1 propensity score-matched analysis was applied. Among 744 patients, 246 undergoing hepatectomy with TAA and 246 undergoing hepatectomy with AA were compared. These patients were matched for baseline characteristics, underlying liver disease, comorbidity, tumor features, and extent of the resection. The rates of morbidity and mortality were the study endpoints.

Enrollment: 744 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• First liver surgery;
• Any type of malignant liver tumor, including hepatocellular carcinoma on cirrhosis.

Exclusion criteria

• Previous history of liver surgery;
• Any type of benign liver tumor;
• Incomplete clinical, surgical, pathological or postoperative data;
• Patients treated with radiofrequency ablation alone or in combination with surgery were also excluded.

Trial design

744 participants in 2 patient groups

TAA

Description:

Thoraco-Abdominal Approach: those patients with liver tumors operated with the thoracic-abdominal approach

Treatment:

Procedure: Hepatectomy

AA

Description:

Abdominal Approach: those patients with liver tumors operated with the abdominal approach (without the thoracotomy)

Treatment:

Procedure: Hepatectomy