Hepatic Blood Flow Changes During Fluid Challenge Assessed by MRI in Volunteers Subjects. (PORTEAU)

Centre Hospitalier Universitaire, Amiens

Status: Completed

Conditions: Hepatic Flow Changes

Treatments: Device: MRI (magnetic resonance imaging)

Study type: Interventional

Funder types: Other

Identifiers

NCT03589261

PI2018_843_0006

Details and patient eligibility

About

Hepatic artery and portal flows are both regulated to assume the whole hepatic blood flow. Each counts for respectively 25% and 75%. That so-called "buffer response" assumes that when portal flow increases, hepatic artery flow decreases. During fluid challenge in intensive care unit, fluid challenge is often administered to improve hepatic perfusion. That observation is not demonstrated. The aim of the study is to test buffer response and portal flow during fluid challenge.

Full description

Prospective monocentric study at Amiens Hospital University. 20 volunteers subjects will be include after providing informed consent. Fluid challenge will be performed with 500 ml of intra venous NaCl (0.9%). Hepatic blood flow measurement will be performed using MRI.

Enrollment: 22 patients

Sex: All

Ages: 18 to 30 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Fasting for the last 12 hours.

Exclusion criteria

• Claustrophobia
• Any previous medical history disease;
• Any abdominal surgical disease
• Pregnancy or breastfeeding

Trial design

Primary purpose: Diagnostic

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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22 participants in 1 patient group

MRI (magnetic resonance imaging)

Other group

Description:

Hepatic blood flow baseline will be measured using MRI. Fluid challenge of 500 ml of NaCl 0.9% will be administered during 10 minutes. Before and After fluid challenge, MRI will be performed to compare flow changes.

Treatment:

Device: MRI (magnetic resonance imaging)