Hepatic Insulin Sensitivity and Very Low Density Lipoprotein Triglyceride (VLDL-TG) Kinetics

University of Aarhus

Status: Completed

Conditions: Obesity; Dyslipidemia

Treatments: Other: Glucose clamp

Study type: Interventional

Funder types: Other

Identifiers

NCT01205750

2009-0132

Details and patient eligibility

About

Obesity is associated with dyslipidemia, which is a major risk factor for coronary heart disease. Triglycerides (TG) and cholesterol are transported in the system of lipoproteins, and the metabolism of these lipids in plasma is closely interrelated. Evidence suggests that increased concentration of very low-density lipoprotein triglyceride (VLDL-TG) is a central pathophysiological feature of the lipid and lipoprotein abnormalities in dyslipidemia.

The primary objective of this study is to investigate VLDL-TG kinetics and hepatic insulin sensitivity in age-matched obese and lean, healthy men in the postabsorptive state and during acute hyperinsulinemia using VLDL-TG and glucose tracers.

Full description

Extensive description not included.

Enrollment: 24 patients

Sex: Male

Ages: 20 to 50 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Healthy
• BMI < 25 kg/m2 or > 30 kg/m2
• Informed consent

Exclusion criteria

• Alcohol misuse
• Smoking
• Use of prescription drugs

Trial design

24 participants in 1 patient group

Glucose clamp

Experimental group

Treatment:

Other: Glucose clamp