Hepatic Mitochondrial Function in Sepsis

Professor C ICHAI

Status: Withdrawn

Conditions: Peritonitis; Sepsis

Study type: Observational

Funder types: Other

Identifiers

NCT00889083

IAAM-2009-1

Details and patient eligibility

About

Multi-organ failure due to sepsis is a major cause of death in critically ill patients. But the mechanisms leading to this condition are not fully understood. Mitochondrial dysfunction has been shown in skeletal muscle of critically ill septic patients. Liver is very important in sepsis as it is responsible of the synthesis of several inflammatory proteins. Moreover hepatic failure is associated to a bad outcome.

The aim of this study is to evaluate the hepatic mitochondrial function in sepsis.

Sex: All

Ages: 18 to 80 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Septic group : Peritonitis patients needing surgery
• Non septic group : Patients needing hepatic surgery

Exclusion criteria

• No liver biopsy performed

Trial design

0 participants in 2 patient groups

Control

Description:

Non septic patients needing hepatic surgery

Sepsis

Description:

Septic patients needing surgery for peritonitis