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Hepatic Steatosis and Pituitary Gland Failure, Evaluation by Nuclear Magnetic Resonance (NMR) Imaging (SHAH)

U

University Hospital Center (CHU) Dijon Bourgogne

Status

Completed

Conditions

Pituitary Gland Failure
Hepatic Steatosis

Treatments

Biological: Blood samples
Other: NMR
Other: fibroscan

Study type

Interventional

Funder types

Other

Identifiers

NCT02814240
PETIT NOVARTIS 2014

Details and patient eligibility

About

The investigator put forward the hypothesis that liver fat mass in patients with pituitary gland failure is greater than that in a control population. Failure of the anterior pituitary and more particularly impaired production of growth hormone (GH) could be the principal mechanism responsible for increased liver fat mass in these patients.

Enrollment

21 patients

Sex

All

Ages

18+ years old

Volunteers

No Healthy Volunteers

Inclusion criteria

  • Patients who have provided consent
  • Patients over 18 years
  • Patients with pituitary disease (Pituitary adenoma, anterior pituitary failure, craniopharyngioma, empty sella syndrome, hypophysitis, infiltration of the stalk) requiring Magnetic Resonance Imaging (MRI) of the pituitary.

Exclusion criteria

  • Persons without national health insurance
  • Pacemaker (Contra-Indication for MRI)
  • Alcohol consumption greater than 4 glasses a day
  • Any treatment able to increase liver fat content (glitazones, systemic corticoids, immunosuppressants) are forbidden
  • Presence of metallic implants (Contra-Indication for MRI)
  • Claustrophobia
  • Adult under guardianship
  • Pregnant or breast-feeding women
  • Patients with a liver disease other than non-alcoholic steatosis

Trial design

Primary purpose

Other

Allocation

N/A

Interventional model

Single Group Assignment

Masking

None (Open label)

21 participants in 1 patient group

Pituitary gland failure
Experimental group
Treatment:
Biological: Blood samples
Other: NMR
Other: fibroscan

Trial contacts and locations

1

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Central trial contact

Jean-Michel PETIT

Data sourced from clinicaltrials.gov

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