Hepatic Vein Flow During Orthotopic Liver Transplantation as Predictive Factor for Postoperative Graft Function

Henry Ford Health

Status: Completed

Conditions: Postoperative Graft Function

Treatments: Other: NO internvention

Study type: Observational

Funder types: Other

Identifiers

NCT03814031

12156

Details and patient eligibility

About

Hepatic vein flow (HVF) assessment using transesophageal echocardiography (TEE) has a potential to predict postoperative graft function in orthotopic liver transplant (OLT). Investigators will measure HVF using TEE and assess the correlation with postoperative graft function indices such as early allograft dysfunction(EAD), prolonged INR, platelet, and total bilirubin.

Full description

During OLT, intraoperative TEE assessment of HVF (systolic and diastolic) were measured, and adjusted with donor graft weight. This index, HVF index, was assessed for correlation with EAD. HVF was calculated with hepatic vein area (cm2) x hepatic vein velocity (ml/s) in systole and diastole during the neohepatic phase. Investigators did ROC analysis to assess the predictive power for EAD, prolonged INR, platelet, and total bilirubin.

Enrollment: 97 patients

Sex: All

Volunteers: No Healthy Volunteers

Inclusion criteria

Orthotopic liver transplants which uses TEE intraoperatively Must be Piggy back technique

Exclusion criteria

TEE absolute contraindication patient refusal

Trial design

97 participants in 2 patient groups

EAD after orthotopic liver transplantation

Description:

Early allograft dysfunction (EAD), which was defined by the presence of one or more of the following: total bilirubin (t-bil) ≥ 10 mg/dL (171 μmol/L) or, INR ≥ 1.6 on day 7, and ALT/AST \> 2,000 IU/L within the first 7 days.

Treatment:

Other: NO internvention

No EAD after orthotopic liver transplantation

Description:

No EAD

Treatment:

Other: NO internvention