Hepatitis B Virus Reactivation: a Cautionary Event After Liver Transplantation for Patients With Hepatocellular Carcinoma

Zhejiang University

Status: Completed

Conditions: Liver Transplant; Complications

Treatments: Diagnostic Test: Diagnosis of postoperative recurrence of liver cancer

Study type: Observational

Funder types: Other

Identifiers

NCT06114251

CT2023-ZJU-OBS2

Details and patient eligibility

About

Highly active hepatitis B virus (HBV) is known to be associated with poor outcomes in patients with hepatocellular carcinoma (HCC). This study aims to investigate the relationship between HBV status and HCC recurrence after liver transplantation. The study retrospectively analyzed HCC patients undergoing liver transplantation in 2 centers between January 2015 and December 2020. We reviewed post-transplant HBV status and its association with outcomes.

Enrollment: 920 patients

Sex: All

Ages: 18 to 75 years old

Volunteers: No Healthy Volunteers

Inclusion and exclusion criteria

Inclusion Criteria:

• (1) preoperative diagnosis of HBV-related HCC and (2) pathologically confirmed HCC.

Exclusion criteria

• (1) non-HBV-related HCC; (2) simultaneous presence of other tumors; (3) re-transplantation; (4) presence of portal vein tumor thrombus; and (5) a survival time of less than 90 days.

Trial design

920 participants in 2 patient groups

First Affiliated Hospital, Zhejiang University School of Medicine

Treatment:

Diagnostic Test: Diagnosis of postoperative recurrence of liver cancer

Shulan (Hangzhou) Hospital

Treatment:

Diagnostic Test: Diagnosis of postoperative recurrence of liver cancer