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Hepatitis B Virus Vertical Transmission From HIV-HBV Co-infected Women

H

Hopital Lariboisière

Status

Completed

Conditions

Vertical Disease Transmission
HBV

Study type

Observational

Funder types

Other

Identifiers

NCT02044068
Liver003

Details and patient eligibility

About

Vertical HIV transmission has been dramatically reduced by the use of combined antiretroviral therapy in HIV-infected pregnant women. Among the most often used drugs, several have dual activity, against HIV and HBV: lamivudine, emtricitabine, tenofovir. Studies about vertical HBV transmission from HIV-HBV co-infected pregnant women are rare in developed countries. The study hypothesis is a major reduction of the risk of HBV vertical transmission.

Full description

Mother-to-Child HIV transmission has been dramatically reduced by the use of combined antiretroviral therapy in HIV-infected pregnant women, both in developed and in developing countries. Among the most often used drugs, several have dual activity, against HIV and HBV: lamivudine, emtricitabine, tenofovir; they can be used as a combo, as tenofovir+emtricitabine for instance. Studies about vertical HBV transmission from HIV-HBV co-infected pregnant women are rare in developed countries. The study hypothesis is a major reduction of the risk of HBV vertical transmission in this context, justifying this retrospective study.

Enrollment

35 patients

Sex

All

Ages

9 months to 15 years old

Volunteers

No Healthy Volunteers

Inclusion criteria

  • children born in the Maternity Department from HIV-HBV co-infected women
  • whose mother was given a treatment with dual activity (HIV and HBV) during pregnancy

Exclusion criteria

  • no

Trial design

35 participants in 1 patient group

children born from HIV-HBV women
Description:
Studying retrospectively their status for HBs Ag and HBc Ab

Trial contacts and locations

1

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Data sourced from clinicaltrials.gov

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