Hepatitis C Treatment of Inmates (PEGPRI)

Haukeland University Hospital

Status and phase

Terminated

Phase 4

Conditions

Chronic Hepatitis C

Treatments

Procedure: Fast initiation procedure

Study type

Interventional

Funder types

Other

Industry

Identifiers

NCT00209898

12952

Details and patient eligibility

About

Hepatitis C infection is a prevalent chronic disease. It is particularly prevalent among intravenous drug abusers. Bergen fengsel is a regional prison housing 250 inmates, of which as many as 70 are recorded HCV RNA PCR positive annuallly. In this study inmate males and females will be randomized to standard screening and initiation procedure, or to a rapid initiation procedure in the hospital's infectious diseases outpatient clinic. The study aims at studying if rapid inclusion will increase the possibility to conclude treatment while the prisoner still is incarcerated, thus improve the chances of reaching a sustained virologic response, compared to standard inclusion, where prisoners, as other out patients will wait for inclusion for several months.

Enrollment

42 estimated patients

Sex

All

Ages

18+ years old

Volunteers

No Healthy Volunteers

Inclusion criteria

Serologic evidence of chronic hepatitis C infection by an anti-HCV test
Serum HCV-RNA quantifiable at > 600 IU/mL or 1000 copies/mL by the Roche AMPLICOR HCV MONITOR Test, v2.0
Patients with both normal or elevated serum ALT are eligible
Compensated liver disease (Child-Pugh grade A clinical classification)
Patients with cirrhosis or transition to cirrhosis must have an abdominal ultrasonography, CT scan or MRI scan without evidence of hepatocellular carcinoma and a serum AFP < 100 ng/mL within 2 months of randomization
Negative urine or blood pregnancy test (for women of childbearing potential) documented within the 24 hour period prior to first dose of study drug
All fertile males and females receiving RBV must be using two forms of effective contraception during treatment and during the 6 months after treatment ends

Exclusion criteria

Women with ongoing pregnancy or breat feeding
Therapy with any systemic anti-viral, anti-neoplastic or immunomodulatory treatment (including supraphysiologic soses of steroids and radiation) < 6 months prior to the first dose of study drug
Any investigational drug < 6 weeks prior to the first dose of study drug Positive test at screening for anti-HAV IgM Ab, HBsAg, anti-HBsAg, anti-HBc Ab, anti-HIV Ab.
History or evidence of a medical condition associated with chronic liver disease other than HCV (e.g. hemochromatosis, autoimmune hepatitis, metabolic liver disease, alcoholic liver disease, toxin exposures)
History or evidence of bleeding from esophageal varices or other conditions consistent with decompensated liver disease
Neutrophil count < 1500/mm or platelet count < 90,000 cells/mm at screening
Serum creatinine level > 1,5 times the ULN at screening
History of severe psychiatric disease, especially depression. Severe psychiatric disease is defined as treatment with an antidepressant medication or neuroleptica at therapeutic doses for major depression or psychosis, respectively for at least 3 months at any previous time, or any history of the following; a suicidal attempt, hospitalization for psychiatric disease or a period of disability due to psychiatric disease
History of severe seizure disorder or current anticonvulsant disease
History of immunologically mediated disease (e.g. IBD, ITP, LED, AIHA, scleroderma, severe psoriasis or RA etc.)
History or other evidence of chronic pulmonary disease associated with functional limitation
History of major organ transplantation with an existing functional graft
History of severe cardiac disease (e.g. NYHA Functional Class III or IV, myocardial infarction within 6 months of ventricular arrhythmias requiring ongoing treatment, unstable angina or other significant CVD)
History or other evidence of severe illness, malignancy or other conditions which would make the patient, in the opinion of the investigator, unsuitable for the study
Evidence of severe retinopathy (e.g. CMV retinitis, macula degeneration)
Evidence of ongoing drug abuse (including excessive alcohol consumption)
Inability or unwillingness to provide informed consent or abide by the requirements of the study
Male partners of women who are pregnant
Hemoglobin < 12 g/dL in women or < 13g/dL in men at screening
Any patient with an increased baseline risk for anemia or for whom anemia would be medically problematic
Patients with documented or presumed coronary artery disease or cerebrovascular disease should not be enrolled if, in the judgement of the investigator, an acuter decrease in hemoglobin by up to 4 g/dL would not be well-tolerated