Hepatoprotective Effect of Remote vs Local Preconditioning of Liver

University Hospital Dubrava

Status

Completed

Conditions

Liver Metastases

Treatments

Procedure: Preconditioning

Study type

Interventional

Funder types

Other

Identifiers

NCT03130920

UHDubrava

Details and patient eligibility

About

The aim of this study is to evaluate hepatoprotective effect from ischemia-reperfusion injury of remote ischemic preconditioning of the liver against local ischemic preconditioning of the liver during human liver resections.

Full description

In this randomized control study, a total of 60 patients were randomized into 3 groups: remote ischemic precondition group - RIPC (3 intervals of 5 minute right upper limb ischemia with 3 intervals of 5 minute reperfusion), local ischemic precondition group - LIPC (15 minutes of inflow liver occlusion followed by 10 minutes of reperfusion before liver transection), control group - CG (group without ischemic preconditioning before liver transection). Patients were also stratified according to the extent of the hepatectomy. Hepatoprotective effect was evaluated by comparing serum transaminase levels, bilirubin levels, albumin, and protein levels, coagulograms and pathohistological exams. We also measured flow rate by Doppler ultrasound of hepatic artery and portal vein before and after preconditioning.

Enrollment

60 patients

Sex

All

Ages

30 to 80 years old

Volunteers

No Healthy Volunteers

Inclusion criteria

patients with colorectal cancer liver metastasis all of which signed an informed consent

Exclusion criteria

having any other underlying liver disease, or preoperative increased liver transaminase, bilirubin
patients with chronic cardiac, pulmonary or renal disease