Hepatorenal Dysfunctions Among Workers Exposed To Petroleum Products

Assiut University

Status: Unknown

Conditions: Petroleum Product Toxicity

Treatments: Diagnostic Test: kidney function tests; Diagnostic Test: Liver function tests.

Study type: Observational

Funder types: Other

Identifiers

NCT04815512

HRDs in petroleum workers

Details and patient eligibility

About

The aim of this study is to assess the liver and renal functions of individuals who are occupationally exposed to petroleum products.

Full description

Certain peoples have a greater risk of exposure to gasoline vapors; these include filling-station workers, service station attendants, drivers of gasoline trucks and refinery workers.Benzene is metabolized in the liver by cytochrome P450 (CYP) 2E1 to benzene oxide. The metabolites undergo further metabolism through oxidation, dehydrogenation or conjugation with sulfate or glucuronic acid . Activation of benzene and its reactive metabolites leads to continuous production of reactive oxygen species (ROS), which leads to lipid peroxidation and damages DNA, RNA, leading to genetic modification and alterations in the functions of important enzymes (i.e. liver) and proteins .

Volatile organic compounds such as gasoline and other fuels are associated with a wide variety of deleterious health effects including liver and kidney diseases. A comparative cross sectional study was conducted from January 2018 to April 2018 at Mekelle city, Tigray region, Northern Ethiopia among gasoline station workers and reporting that the mean level of ALT, AST, Urea, creatinine, and uric acid was significantly higher among gasoline stations workers when compared to control study participants and there was also a significant increase in ALT, AST, Urea, creatinine and uric acid among gasoline stations with increase duration of exposure .

Enrollment: 56 estimated patients

Sex: Male

Ages: 20 to 60 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

for exposed group:

• Apparently health workers who exposed for petroleum products in The Petroleum Pipelines Company in assiut will be included in the study

Exclusion criteria

for exposed and Comparison groups

• history of hepatic and renal health problem
• history of taking medications affecting liver and renal function tests

Trial design

56 participants in 2 patient groups

exposed group

Description:

workers in The Petroleum Pipelines Company who are occupationally exposed to petroleum products will be included in the study.

Treatment:

Diagnostic Test: kidney function tests

Diagnostic Test: Liver function tests.

Comparison group (control group)

Description:

healthy administrative workers in assiut university

Treatment:

Diagnostic Test: kidney function tests

Diagnostic Test: Liver function tests.