Hepcidin Behavior in Patients With Obesity and Bariatric Surgery (HOBS)

Universitaire Ziekenhuizen KU Leuven

Status

Terminated

Conditions

Hepcidin

Treatments

Other: Blood sampling

Study type

Observational

Funder types

Other

Identifiers

NCT03990948

S62085

Details and patient eligibility

About

Iron deficiency is one of the most common nutritional problems observed in patients with obesity and after bariatric surgery. From a therapeutic point of view, iron deficiency can lead to iron deficiency anemia. Iron supplementation carries the risk of exacerbating infections, altering the gut microbiome and iron overload. Therefore, it would be beneficial to use iron supplementation only in truly iron deficient patients. To date, different studies have observed that hepcidin could be a possible indicator of iron status and absorption in different patient populations. Furthermore, it could be used to distinguish anemia due to iron deficiency from inflammation and globin disorder related anemia. How hepcidin concentrations variate in patients with obesity and after bariatric surgery remains unsure.

Full description

During the visit in the obesity clinic, eligible patients will be approached for participation by the sub-investigator. Interested patients will receive information regarding the study and receive the information sheet containing the informed consent form. After signing the informed consent form, general information will be collected regarding medical and demographic data using a short questionnaire. Additional questionnaires regarding demographics and menstrual cycle will be collected. Anthropometric measurements will be collected for the determination of the length, weight, hip circumference, waist circumference and body composition. Finally, blood samples will be collected for the determination of iron and inflammation related markers.

Enrollment

300 patients

Sex

All

Ages

18+ years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

The patient has to be 18 years or older
Written informed consent has to be obtained after being informed on all aspects of the study
The patient has a BMI > 30 kg/m² OR There has to be at least one year between the primary RYGB and the participation in the study OR There has to be at least one year between the primary SG and the participation in the study

Exclusion criteria

Patients younger than 18 years old
Women who are pregnant or are breastfeeding
Post-menopausal women, defined as at least 6 months of amenorrhea after the final menstrual period
Inability to follow the procedures of the studies due to language problems
Patients who have had more than one bariatric surgery