Hepcidin Levels in Periodontal Health and Disease

Bulent Ecevit University

Status: Completed

Conditions: Periodontal Diseases

Treatments: Other: Biomarker test

Study type: Observational

Funder types: Other

Identifiers

NCT03789565

hepcidin

Details and patient eligibility

About

Periodontal disease refers to inflammatory disease of the periodontium caused by the host and/or pathogenic microorganisms. Anti-inflammatory and pro-inflammatory cytokines play a role in the periodontal inflammation process. The aim of this study was to evaluate the levels of hepcidin, interleukin (IL)-6, and IL-10 levels in gingival crevicular fluid (GCF) and in serum samples obtained from individuals with periodontal inflammation.

Full description

The study included 90 individuals, who were divided into three groups: periodontally healthy (PH) (n=30); gingivitis (G) (n=30); and chronic periodontitis (CP) (n=30). GCF and serum samples were obtained from each individual, and samples were evaluated using ELISA. Statistical evaluation of the data was performed using the SPSS packet data program.

Enrollment: 90 patients

Sex: All

Ages: 32 to 52 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Systematically healthy patients. Patients who did not receive any medication or periodontal treatment within the previous 6 months

Exclusion criteria

• Individuals who smoked and women who were pregnant and/or lactating were excluded from the study

Trial design

90 participants in 3 patient groups

Group 1. Healthy individuals from periodontal perspective:

Description:

GI \< 1, PD ≤ 3 mm, CAL = 0 mm, with no apparent bone loss on radiography.

Treatment:

Other: Biomarker test

Group 2. Individuals diagnosed with Gingivitis

Description:

GI \> 1, PD ≤ 3 mm, CAL = 0 mm, with no apparent bone loss on radiography.

Treatment:

Other: Biomarker test

Group 3. Individuals diagnosed with CP

Description:

GI \> 1, PD ≥ 5 mm, CAL ≥ 3 mm, with apparent bone loss on radiography.

Treatment:

Other: Biomarker test