Hesperidin and Diosmin Effect on Metabolic Syndrome

Beni-Suef University

Status: Completed

Conditions: Metabolic Syndrome and Diabetic Neuropathy

Treatments: Dietary Supplement: dietary supplement flavonoids

Study type: Interventional

Funder types: Other

Identifiers

NCT05243238

FMBSU REC FWA#: FWA00015574

Details and patient eligibility

About

The components of metabolic syndrome (MetS), particularly obesity and dyslipidemia, are linked to peripheral neuropathy (PN) among patients with diabetes or even without diabetes. Several studies revealed that complementary and herbal medicine could provide a potential for PN management and MetS components. Thus, designing clinical trials with interventions combinations to achieve a considerable improvement is highly recommended. Hesperidin and diosmin, citrus-derived flavonoids, have been reported to possess anti-hyperlipidemic, anti-inflammatory, analgesic, antioxidant, antidiabetic, and anti-hypertensive effect with high tolerability and safety profile

Enrollment: 129 patients

Sex: All

Ages: 18 to 70 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

Type 2 diabetes adult patients who meet metabolic syndrome criteria and with diabetic neuropathy

Exclusion criteria

patients without any parameter of inclusion criteria

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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129 participants in 4 patient groups

Hesperidin group

Active Comparator group

Treatment:

Dietary Supplement: dietary supplement flavonoids

Diosmin

Active Comparator group

Treatment:

Dietary Supplement: dietary supplement flavonoids

Hesperidin and diosmin

Active Comparator group

Treatment:

Dietary Supplement: dietary supplement flavonoids

control group

No Intervention group