Heterogeneity of Tertiary Lymphoid Structures Predicts Distinct Malignancy and Immune Microenvironment in Prostate Cancer: a Retrospective Cohort Study

Fudan University

Status: Completed

Conditions: Prostate Cancer

Study type: Observational

Funder types: Other

Identifiers

NCT06484127

050432-4-2307E

Details and patient eligibility

About

The aim of this study was to reveal the predictive value of spatial heterogeneity and maturity difference of tertiary lymphoid structure in pathological sections of prostate cancer patients for clinical features and prognosis. It provides a new idea for the selection of prostate cancer immunotherapy population in the future.

Enrollment: 200 patients

Sex: Male

Volunteers: No Healthy Volunteers

Inclusion criteria

1.patients diagnosed with prostate cancer who underwent radical prostatectomy or prostate puncture

Exclusion criteria

1. incomplete medical records, inadequate follow-up information, and confirmed non-prostatic acinar adenocarcinoma.

Trial design

200 participants in 2 patient groups

tertiary lymphoid structure positive patients

tertiary lymphoid structure negative patients