Heterotopic Ossification in Abdominal Incision and Pancreatic Cancer

Nanjing Medical University

Status: Not yet enrolling

Conditions: Cancer of Pancreas; Ossification, Heterotopic

Treatments: Diagnostic Test: Bone alkaline phosphatase; Radiation: Abdominal CT scan

Study type: Observational

Funder types: Other

Identifiers

NCT04049461

NMU-JSPH-PC-Ossification

Details and patient eligibility

About

To investigate whether pancreatic cancer is the cause of heterotopic ossification of abdominal incision.

Full description

Heterotopic ossification of abdominal incision (HOAI) has long been regarded as a rare complication after general surgery. However,according to our retrospective analysis. HOAI was more frequently observed in the malignancy group (33/121 cases, 27.3%) than in the non- malignancy group. Because of the many biases in the retrospective analysis, the result was not widely shared.

The purpose of this prospective study is to confirm that pancreatic cancer is the cause of heterotopic ossification of abdominal incisions. According to postoperative pathology, the patients were divided into two groups: pancreatic cancer group and benign diseases group.The researchers will observe whether patients develop heterotopic ossification of the abdominal incision one year after surgery to conclude.

Enrollment: 105 estimated patients

Sex: All

Ages: 18 to 80 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Obtain informed consent from the patients.
• The patient's abdominal incision was double-closed with continuous suture of linea alba and fascia with absorbable suture, and skin was sutured with skin staples.

Exclusion criteria

• Refusing to join the study
• Previous history of malignant tumor
• Previous history of midabdominal incision
• Abnormal calcium and phosphorus metabolism
• Distant metastasis
• Palliative operation
• performing neoadjuvant chemotherapy

Trial design

105 participants in 2 patient groups

PDAC Group

Description:

Radical operations were performed through central abdominal incisions. The postoperative pathology was pancreatic ductal adenocarcinoma.

Treatment:

Diagnostic Test: Bone alkaline phosphatase

Radiation: Abdominal CT scan

Benign Group

Description:

The abdominal midline incision was performed and the postoperative pathology was benign.

Treatment:

Diagnostic Test: Bone alkaline phosphatase

Radiation: Abdominal CT scan