HFNC vs Nasal Cannula in Mild Chronic Obstructive Pulmonary Disease Exacerbation

China-Japan Friendship Hospital

Status: Unknown

Conditions: COPD Exacerbation

Treatments: Device: High flow nasal cannula

Study type: Interventional

Funder types: Other

Identifiers

NCT03003559

2016YFC1304304-1

Details and patient eligibility

About

For AECOPD patients, only 8% patients ventilated by noninvasive and invasive positive pressure ventilation. Nasal cannula is the most common pattern of oxygen therapy in mild AECOPD. As a low flow oxygen therapy, nasal cannula has many disadvantages.Therefore, we design a randomized controlled trial(RCT)to explore whether HFNC would be better than nasal cannula to prevent the aggravation of respiratory failure and endotracheal intubation in mild AECOPD.

Full description

For AECOPD patients, most of patients don't need respiratory support, only 8% patients ventilated by noninvasive and invasive positive pressure ventilation. Nasal cannula is the most common pattern of oxygen therapy in mild AECOPD. As a low flow oxygen therapy, nasal cannula has many disadvantages: discomfort, low humidity and unstable fraction of inspired oxygen(FiO2) in inspiratory gas. Therefore, we design a RCT to explore whether HFNC would be better than nasal cannula to prevent the aggravation of respiratory failure and endotracheal intubation in mild AECOPD.

Enrollment: 328 estimated patients

Sex: All

Ages: 18 to 85 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• AECOPD; pH≥7.35, PaCO2>45 mmHg

Exclusion criteria

• Need to be intubated immediately; refuse to engage in the study; severe organ dysfunction

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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328 participants in 2 patient groups

High flow nasal cannula

Experimental group

Description:

High flow nasal cannula(OptiflowTM); Flow 25-60 L/min is set according to patients' comfort; FiO2 is adjusted to maintain peripheral capillary oxygen saturation(SpO2) 90-95%; temperature is set at 37.

Treatment:

Device: High flow nasal cannula

Nasal cannula

No Intervention group

Description:

Nasal cannula;set oxygen flow to keep SpO2 90-95%