HFNC vs NPPV After Early Extubation for Patients With COPD

Chinese PLA General Hospital (301 Hospital)

Status: Unknown

Conditions: Hypercapnic Respiratory Failure; COPD

Treatments: Device: HFNC; Device: NPPV

Study type: Interventional

Funder types: Other

Identifiers

NCT04156139

2018ZX09201013

Details and patient eligibility

About

High-flow nasal cannula oxygen therapy(HFNC) has proved no significant difference compared with noninvasive positive pressure ventilation (NPPV) in preventing postextubation respiratory failure and reintubation in patients with acute hypoxemic respiratory failure.However, the efficacy of early postextubation sequential HFNC in COPD patients with hypercapnic respiratory failure is inconclusive.

Full description

The investigators conducted this prospective randomized controlled trial to explore the efficacy, safety of HFNC versus NPPV after early extubation in COPD patients with hypercapnic respiratory failure.The investigators hypothesized that the efficacy of HFNC after early extubation is non-inferior to that of NPPV.

Enrollment: 502 estimated patients

Sex: All

Ages: 40 to 85 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• 1. COPD patients with bronchopulmonary infection 2. Patients with hypercapnia respiratory failure treated with invasive mechanical 3.14 days ≥ invasive mechanical ventilation ≥ 48 hours; 4.Reached the pulmonary infection control (PIC) window; 5.Have self-care ability with oxygen supply during stable phrase

Exclusion criteria

• Severe organ dysfunction;Myopathy or myasthenia gravis;Upper airway obstruction;A large amount of secretions and inability to drain;

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

---

502 participants in 2 patient groups

Control group

Active Comparator group

Description:

NPPV treatment for patients will be performed for patients immediately after extubation in control group.

Treatment:

Device: HFNC

Device: NPPV

intervention group

Experimental group

Description:

HFNC treatment will be performed for patients immediately after extubation in the intervention group.

Treatment:

Device: HFNC

Device: NPPV