High Dose and Low Dose of Atorvastatin in Patients With Unstable Angina and NSTEMI (Non ST Elevation MI)

Hormozgan University of Medical Sciences

Status: Completed

Conditions: Cardiovascular Disease

Treatments: Drug: Low dose Atorvastatin; Drug: High dose atorvastatin

Study type: Interventional

Funder types: Other

Identifiers

NCT01306565

Atorvastatin and CRP level

Details and patient eligibility

About

The aim of this study is to compare the effect of high dose and low dose of Atorvastatin in reduction level of C-reactive protein (CRP) in patients with unstable angina and NSTEMI (Non ST Elevation MI) attending Shahid Mohammadi hospital in Bandar Abbas.

Full description

This study compare the effect of 80mg atorvastatin followed by two 20mg daily atorvastatin with three 80mg daily atorvastatin in reduction of CRP in patients with unstable angina and NSTEMI (Non ST Elevation MI) attending Shahid Mohammadi hospital in Bandar Abbas in 2009.

Enrollment: 100 patients

Sex: All

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patients with unstable angina with chest discomfort at rest with normal EKG or St depression (at least 0.1mv) in two consecutive leads or new and deep T inversion (at least 0.2mv)

Exclusion criteria

• Myocardial Infarction with ST elevation
• Diabetes Mellitus
• Previous statin use
• Current infectious disease

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Triple Blind

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100 participants in 2 patient groups

High dose atorvastatin

Active Comparator group

Description:

Three 80mg daily doses of atorvastatin

Treatment:

Drug: Low dose Atorvastatin

Low dose Atorvastatin

Experimental group

Description:

80mg atorvastatin followed by two 20mg daily atorvastatin

Treatment:

Drug: High dose atorvastatin