High Dose Candesartan Versus Quinapril for Restenosis Prophylaxis After Stent Angioplasty

Technische Universität Dresden

Status: Completed

Conditions: Arterial Occlusive Diseases

Treatments: Drug: candesartan (drug) or quinapril (drug)

Study type: Interventional

Funder types: Other

Identifiers

NCT00154050

IKPD KARDCHEM 02-04

Details and patient eligibility

About

The study is designed to test the hypothesis that high dose candesartan treatment compared to quinapril is able to reduce intima hyperproliferation and the restenosis rate after stent angioplasty in peripheral occlusive artery disease.

Full description

Patients are randomly assigned to treatment with either candesartan 32 mg/d or Quinapril 20 mg/d before the angioplasty. Walking distance, intima media thickness and crurobrachial pressure ratios are compared after 6 weeks, 3 months and 6 months. After 6 months an angiographic control is performed.

Sex: All

Ages: 18 to 80 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• male and female
• peripheral occlusive arterial disease Stad IIb Fontaine classification

Exclusion criteria

• patients with lesions not available for PTA
• renal insufficiency
• patients on calcium-antagonists

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind