High-dose L-Carnitine and Diaphragmatic Function Assessed by Ultrasonography in Patients With Respiratory Failure.

Ain Shams University

Status and phase: Completed; Phase 4

Conditions: Respiratory Failure

Treatments: Drug: L-Carnitine ( high dose); Drug: L Carnitine ( low dose)

Study type: Interventional

Funder types: Other

Identifiers

NCT05322447

R / 2022

Details and patient eligibility

About

L-Carnitine supplementation has been shown to boost muscular performance in several studies. In hemodialysis patients with muscular weakness, fatigue, or cramps/aches, after L-carnitine treatment, about two-thirds of patients had at least some improvement in muscular symptoms . L-Carnitine was also found to improve the left ventricular ejection fraction (LVEF) in hemodialysis patients with cardiac morbidity who had significantly reduced LVEF in echocardiography before supplementation. Moreover, L-Carnitine has been shown to improve muscular function and exercise performance in athletes in several studies

Enrollment: 60 patients

Sex: All

Ages: 21+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Age from 21 years old or greater
• Both genders have respiratory failure either of the primary medical origin or in the post-surgical course.
• Not in need of mechanical ventilation

Exclusion criteria

• Renal failure on regular dialysis
• Hypothyroidism
• Seizures
• End-stage liver disease
• Mechanical ventilation
• History or discovered allergy to L-carnitine, pivampicillin, and other pivalate-conjugated antibiotics.

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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60 participants in 2 patient groups

Control Group

Other group

Description:

maintenance dose of L- carnitine 6 gm/day to keep normal level (normal L-carnitine level is normal 25-50 mmol/L)

Treatment:

Drug: L Carnitine ( low dose)

experimental group

Experimental group

Description:

high dose of L- Carnitine 18 gm/day as a continuous intravenous infusion to reach double the normal plasma level.

Treatment:

Drug: L-Carnitine ( high dose)