High-dose Periop Statins for Prevention of DVT

Yale University

Status: Completed

Conditions: Gynecologic Oncological Pelvic/Abdominal Surgery

Treatments: Drug: atorvastatin

Study type: Interventional

Funder types: Other

Identifiers

NCT00259662

HIC0507000393

Details and patient eligibility

About

This study is designed to determine if the use of atorvastatin (Lipitor), a member of the HMG coA reductase inhibitor class of drugs referred to as statins, will reduce inflammatory responses and deep vein thrombosis formation when given in high doses in the perioperative period.

Enrollment: 29 patients

Sex: Female

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• gynecologic tumor scheduled for resection

Exclusion criteria

• prior reaction to statins
• renal insufficiency
• liver disease
• h/o alcoholism
• prior h/o DVT or hypercoagulability
• concurrent medications that significantly affect cytochrome P450 3A4
• breast feeding or pregnancy