High-fat Meal Challenge in Pediatrics

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Dartmouth Health

Status

Completed

Conditions

Insulin Resistance
Pediatric Obesity

Treatments

Dietary Supplement: High-fat Challenge

Study type

Interventional

Funder types

Other

Identifiers

NCT05230433
STUDY02001316

Details and patient eligibility

About

The objective is to determine if how physical fitness, measured using a treadmill maximal oxidative capacity test, is associated with the capacity to metabolize a high-fat meal in pediatrics (ages 8-17 years). Ability to metabolize the meal will be assessed by profiling mitochondrial and extra-mitochondrial fatty acid metabolites. The investigators will test if fatty acid oxidation mediates the relationship between fitness and markers of metabolic health, such as insulin resistance.

Enrollment

15 patients

Sex

All

Ages

8 to 17 years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

Children ages 8-17 years with a BMI-percentile ≥ 5th.

Exclusion criteria

  • Previous diagnosis of type 1 or 2 diabetes.
  • Use of concurrent medications known to affect glucose metabolism (metformin, oral steroids, sulfonylureas, insulin).
  • Evidence of inherited disorders of lipid metabolism.
  • Inability to participant in the maximal aerobic capacity test on the treadmill.
  • Allergies to palm oils or protein types within high-fat challenge, such as lactose and soy.
  • Individuals who cannot speak and/or write in English.

Trial design

Primary purpose

Basic Science

Allocation

N/A

Interventional model

Single Group Assignment

Masking

None (Open label)

15 participants in 1 patient group

High-fat Metabolic Challenge
Experimental group
Description:
Participants will consume a high-fat agent one time, at the second study visit.
Treatment:
Dietary Supplement: High-fat Challenge

Trial contacts and locations

0

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Data sourced from clinicaltrials.gov

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