High-fat Meal Challenge in Pediatrics

Dartmouth Health

Status: Completed

Conditions: Insulin Resistance; Pediatric Obesity

Treatments: Dietary Supplement: High-fat Challenge

Study type: Interventional

Funder types: Other

Identifiers

NCT05230433

STUDY02001316

Details and patient eligibility

About

The objective is to determine if how physical fitness, measured using a treadmill maximal oxidative capacity test, is associated with the capacity to metabolize a high-fat meal in pediatrics (ages 8-17 years). Ability to metabolize the meal will be assessed by profiling mitochondrial and extra-mitochondrial fatty acid metabolites. The investigators will test if fatty acid oxidation mediates the relationship between fitness and markers of metabolic health, such as insulin resistance.

Enrollment: 15 patients

Sex: All

Ages: 8 to 17 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Children ages 8-17 years with a BMI-percentile ≥ 5th.

Exclusion criteria

• Previous diagnosis of type 1 or 2 diabetes.
• Use of concurrent medications known to affect glucose metabolism (metformin, oral steroids, sulfonylureas, insulin).
• Evidence of inherited disorders of lipid metabolism.
• Inability to participant in the maximal aerobic capacity test on the treadmill.
• Allergies to palm oils or protein types within high-fat challenge, such as lactose and soy.
• Individuals who cannot speak and/or write in English.

Trial design

Primary purpose: Basic Science

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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15 participants in 1 patient group

High-fat Metabolic Challenge

Experimental group

Description:

Participants will consume a high-fat agent one time, at the second study visit.

Treatment:

Dietary Supplement: High-fat Challenge