High-fiber Diet on the Body and the Brain

Max Planck Institute for Human Cognitive and Brain Sciences

Status

Completed

Conditions

Overweight

Diet Modification

Treatments

Dietary Supplement: maltodextrin

Dietary Supplement: inulin

Study type

Interventional

Funder types

Other

Identifiers

NCT03829189

GUT_BRAIN

Details and patient eligibility

About

The central research question aims to understand what drives individuals to make and maintain a vegan / vegetarian dietary decision, to investigate whether there are possible predictors that might influence such a decision and whether personality differences already exist or can only be measured after the change in diet. The investigators will examine the effects of a high-fiber diet on food wanting on a neural and on a behavioral level. The microbiome is suggested to mediate the expected changes in food wanting.

Enrollment

61 patients

Sex

All

Ages

18 to 45 years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

body-mass-index 25-30kg/m^2
females on contraception only

Exclusion criteria

current neurological or psychiatric illness
daily consumption of more than 50 g of alcohol, more than 10 cigarettes or more than 6 cups of coffee
use of antidepressants or other centrally acting drugs
type 2 diabetes mellitus or other serious metabolic disorders
MRI contraindication (e.g. cardiac pacemaker, drug pump, shunts)
major untreated medical condition, including gastrointestinal organs, lungs, heart, cardiovascular system, liver and kidney)
diet-related restrictions (food allergies, food intolerances, known nutrient deficiencies or a recent history of dieting or restrictive eating behaviour, including vegan, vegetarian diet)
current pregnancy or lactation