High-field Brain Magnetic Resonance Spectroscopy

University of Minnesota (UMN)

Status: Active, not recruiting

Conditions: Healthy

Study type: Observational

Funder types: Other; NIH

Identifiers

NCT02053701

1210M23141

P41EB015894 (U.S. NIH Grant/Contract)

Details and patient eligibility

About

Magnetic resonance spectroscopy (MRS) allows non-invasive measurement of the concentration of up to 18 metabolites in the brain ("neurochemical profile").

The objective of this proposal is to develop new methods for high-field brain MRS (3 to 7 Tesla).

Our main hypothesis is that higher magnetic fields lead to improved spatial and temporal resolution and improved quantification precision.

Aims

1. To obtain improved "neurochemical profiles" in the brain using single voxel proton MRS at very high field (3 Tesla to 7 Tesla).
2. To develop new methods for proton magnetic resonance spectroscopic imaging (MRSI) to obtain metabolic maps at very high field (3 Tesla to 7 Tesla).

Since this project is focused on technical development, only healthy volunteers will be recruited (no patients).

Enrollment: 30 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• over 18 years old

Exclusion criteria

• no metallic implant or other MRI-incompatible device