High-Field MRI Characterization of Wrist and Hand Cartilage Abnormalities in Inflammatory and Chronic Rheumatisms

Public Assistance-Hospitals of Marseille (AP-HM)

Status: Completed

Conditions: Inflammation; Rheumatism; Abnormality

Treatments: Other: high-field MRI (3 Teslas)

Study type: Interventional

Funder types: Other

Identifiers

NCT01058161

2009 28 (Other Identifier)

2009-A01040-57

Details and patient eligibility

About

The present project aims at evaluating the diagnostic potential of high-field MRI (3 Teslas) for joint disease. At this field, given that isotropic image resolution of 400 microns can be obtained, one could expect an early detection of joint abnormalities. The additional aim of this project will be to develop a quantitative analyse of the corresponding high-resolution images.

Enrollment: 34 patients

Sex: All

Ages: 18+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• gp Suspects or affected by rheumatoid polyarthritis

  1. Morning articular Stiffness of at least 15 minutes.
  2. Arthalgias or Arthritises of at least three joints(articulations), among which those of the hand.
  3. Possible rheumatoid Presence of a factor(mailman) and\or Antibody anti peptides positive citrullinés.
  4. Typical possible radiological Hurts on the standard clichés(pictures) of the reached(affected) joints(articulations).

• gp Affected by stiffening spondylitis with axial and peripheral infringement :

  . Lumbago and steepness lumbar vertebra inflammatory. 2. Arthralgias and\or peripheral arthritises 3. Possible presence of an allèle HLA 4. Possible presence of a sacro-illite 5. Absence of the other rheumatic markers

• gp Affected by connectivity with anti-nuclear antibody positive and / or specific antibodies, suffering of polyarthralgias with or without arthritis

• gp Healthy control

• gp Presenting a degenerative osteoarthritis of the wrist traumatic comment, noticed radiologically, which will serve as not inflammatory control.

Exclusion criteria

• Claustrophobia,
• metallic foreign bodies,
• pacemakers The pregnant women,
• parturients or who breast-feed are excluded from the study

Trial design

Primary purpose: Diagnostic

Allocation: Non-Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

---

34 participants in 5 patient groups

Suspects or affected by rheumatoid polyarthritis

Other group

Treatment:

Other: high-field MRI (3 Teslas)

Other: high-field MRI (3 Teslas)

Other: high-field MRI (3 Teslas)

Other: high-field MRI (3 Teslas)

stiffening spondylitis with axial and peripheral infringement

Other group

Treatment:

Other: high-field MRI (3 Teslas)

Other: high-field MRI (3 Teslas)

Other: high-field MRI (3 Teslas)

Other: high-field MRI (3 Teslas)

polyarthralgies with or without arthritis

Other group

Description:

Affected by connectivity with anti-nuclear antibody positive and / or specific antibodies, suffering of polyarthralgias with or without arthritis

Treatment:

Other: high-field MRI (3 Teslas)

Other: high-field MRI (3 Teslas)

Other: high-field MRI (3 Teslas)

Other: high-field MRI (3 Teslas)

Healthy control

Other group

Treatment:

Other: high-field MRI (3 Teslas)

Other: high-field MRI (3 Teslas)

Other: high-field MRI (3 Teslas)

Other: high-field MRI (3 Teslas)

not inflammatory control

Other group

Description:

Presenting a degenerative osteoarthritis of the wrist traumatic comment, noticed radiologically, which will serve as not inflammatory control.

Treatment:

Other: high-field MRI (3 Teslas)

Other: high-field MRI (3 Teslas)

Other: high-field MRI (3 Teslas)

Other: high-field MRI (3 Teslas)