High-Flow Nasal Cannula (HFNC) Preoxygenation in Obese Patients Undergoing General Anesthesia

Free University of Brussels (ULB)

Status: Completed

Conditions: Preoxygenation; Obesity; Anesthesia

Treatments: Device: High Flow Nasal Cannula (HFNC); Device: Standard anesthesia FaceMask (FM)

Study type: Interventional

Funder types: Other

Identifiers

NCT03615417

P2018/067 (Other Identifier)

SRB-201712-161

B406201834736 (Other Identifier)

Details and patient eligibility

About

This study aims to evaluate the effectiveness of the High Flow Nasal Cannula (HFNC) for the preoxygenation of obese patients undergoing a general anesthesia. The HFNC interface is compared to a standard anesthesia FaceMask (FM) preoxygenation with Continuous Positive Airway Pressure (CPAP), the current gold standard procedure for obese induction.

The interest of HFNC preoxygenation is to increase the "safe apnea time" before critical arterial desaturation, useful in the management of difficult airways, especially in subjects with reduced respiratory reserves such as the obese.

Enrollment: 40 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Surgery with the need for general anesthesia with muscle relaxation
• ASA (American Society of Anesthesiologists) physical status score II-III
• BMI > 35

Exclusion criteria

• Severe respiratory disease (acute respiratory failure, Chronic obstructive pulmonary disease COPD, parenchymal pneumopathies,...)
• Severe nasal pathology (malformation, stenosis)
• Criteria or previous difficult intubation
• BMI > 50
• Chest circumference > 150cm
• Implanted electronic device (pacemaker, neurostimulator, ...)
• Pregnancy

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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40 participants in 2 patient groups

HFNC - High Flow Nasal Cannula

Experimental group

Description:

Participants are preoxygenated by High Flow Nasal Cannula (HFNC) OptiFlow.

Treatment:

Device: High Flow Nasal Cannula (HFNC)

FM - FaceMask

Active Comparator group

Description:

Participants are preoxygenated by standard anesthesia FaceMask.

Treatment:

Device: Standard anesthesia FaceMask (FM)