High Flow Nasal Cannula Versus Nasal Continuous Positive Airway Pressure

Christiana Care Health Services

Status: Completed

Conditions: Respiratory Insufficiency

Treatments: Other: Pulmonary Function Testing & esophageal pressure monitoring; Other: Pulmonary function testing and esophageal pressure

Study type: Interventional

Funder types: Other

Identifiers

NCT01531465

31073

Details and patient eligibility

About

The purpose of this study is to compare two common methods of providing respiratory support: nasal continuous airway pressure and high flow nasal cannula to see what effect it has on babies breathing. The investigators also will compare the effects of slightly changing the level of support these two different types of therapy on how easily your baby is breathing. Changes in the level of support and between these two respiratory support modalities are frequently done and are part of the routine care in the neonatal intensive care unit.

Enrollment: 20 patients

Sex: All

Ages: 2 days to 6 months old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Infants who are between 28 and 40 weeks of corrected gestational age at the time of study entry
• Currently on high flow nasal cannula receiving 3 to 5 lpm or on nasal continuous positive airway pressure at 5 to 6 cmH2P with and FiO2 requirement </= 40% by the clinical care team for clinical care purposes.
• On current mode of support for >/= 12 hours and have been extubated from a mechanical ventilator for >/= 48 hours.

Exclusion criteria

• Infants with skeletal or neuromuscular disorders that affect the accuracy of RIP PFT measurements.

Trial design

Primary purpose: Basic Science

Allocation: Non-Randomized

Interventional model: Crossover Assignment

Masking: None (Open label)

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20 participants in 2 patient groups

HFNC to NCPAP

Other group

Description:

Infants who are currently on HFNC.

Treatment:

Other: Pulmonary function testing and esophageal pressure

NCPAP to HFNC

Other group

Description:

Infants who are currently on NCPAP.

Treatment:

Other: Pulmonary Function Testing & esophageal pressure monitoring