High Flow Nasal Cannula vs Noninvasive Ventilation in Patients With Hypoxic Respiratory Failure Following Blunt Chest Trauma

Ain Shams University

Status: Completed

Conditions: Blunt Injury of Thorax

Treatments: Device: high flow nasal cannula; Device: noninvasive ventilation

Study type: Interventional

Funder types: Other

Identifiers

NCT05527431

FAMSU R 115/ 2022

Details and patient eligibility

About

to compare high flow nasal cannula against noninvasive ventilation in patients with non-sever blunt chest trauma in improvement of oxygenation, need for intubation and mechanical ventilation within 28 days

Enrollment: 120 patients

Sex: All

Ages: 18 to 80 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Age ≥18 y,
• Willing and able to provide written informed consent prior to performing study procedures,
• currently hospitalized and requiring medical care for non-sever blunt chest trauma (abbreviated injury severity scale ≤ 2) SpO2 90% or less while breathing 10 L/min.

Exclusion criteria

• Contraindications of noninvasive ventilation (face trauma or surgery, airway obstruction, upper gastrointestinal tract bleeding, disturbed level of consciousness), -smoker
• intubation for any cause other than respiratory cause

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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120 participants in 2 patient groups

high flow nasal cannula

Active Comparator group

Treatment:

Device: high flow nasal cannula

noninvasive mechanical ventilation

Active Comparator group

Treatment:

Device: noninvasive ventilation