High Flow Nasal Oxygen Versus Usual Care in COPD Pulmonary Rehabiliation

Changi General Hospital

Status: Unknown

Conditions: Chronic Obstructive Pulmonary Disease

Treatments: Other: High flow nasal oxygen; Other: Usual care

Study type: Interventional

Funder types: Other

Identifiers

NCT03940040

HFO_RCT

Details and patient eligibility

About

To compare the effects of high flow nasal oxygen with usual care during an outpatient 6-week pulmonary rehabilitation program after hospitalization for COPD exacerbation.

Full description

This is a pilot randomized controlled trial to compare the effects of high flow nasal oxygen with usual care during an outpatient 6-week pulmonary rehabilitation program after hospitalization for COPD exacerbation.

Enrollment: 22 estimated patients

Sex: All

Ages: 21+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

1. Age 21 years and above
2. Known diagnosis of COPD based on history AND spirometry demonstrating post bronchodilator FEV1/FVC ratio <0.7
3. Currently admitted inpatient for an acute COPD exacerbation as the primary diagnosis
4. Fit to participate in exercise therapy as determined by both physician and physiotherapist
5. Has the mental capacity to follow instructions
6. Experience shortness of breath on exertion
7. Have decreased ability to carry out activities due to shortness of breath
8. Willing to participate in the exercise program

Exclusion criteria

1. Uncontrolled/ unstable medical conditions such as severe chronic heart failure that make exercise unsafe
2. Pulmonary disorder other than COPD
3. Physical conditions that preclude the ability to participate in exercise or may impair exercise performance.

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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22 participants in 2 patient groups

Usual Care

Active Comparator group

Description:

Patients will under go usual care ( pulmonary rehabilitation on room air or with nasal oxygen supplementation)

Treatment:

Other: Usual care

High flow nasal oxygen

Experimental group

Description:

Patients will undergo pulmonary rehabilitation with high flow nasal oxygen

Treatment:

Other: High flow nasal oxygen