High-flux Hemodialysis Versus Hemodiafiltration for End-Stage Renal Disease

Guangdong Provincial People's Hospital (Guangdong Provincial Academy of Medical Sciences)

Status: Unknown

Conditions: Chronic Kidney Failure

Treatments: Other: Hemodiafiltration; Other: High-flux hemodialysis

Study type: Interventional

Funder types: Other

Identifiers

NCT03456232

GDREC2017324H

Details and patient eligibility

About

This study evaluates the effect of high-flux hemodialysis compared to hemodiafiltration on small and moderate molecule substances clearance. Meanwhile, this study evaluates the effect of high-flux hemodialysis compared to hemodiafiltration on cardiac function. In this self matching study, participants will receive high-flux hemodialysis compared to hemodiafiltration.

Full description

Hemodialysis using diffusion, ultrafiltration and convection principle to remove harmful substances in the blood and excessive water, is one of the most commonly replacement therapy.

Hemodiafiltration is a combination of hemodialysis and hemofiltration with two modes of treatment advantages, both by diffusion and convection principle to remove harmful substances in the blood.

Enrollment: 40 estimated patients

Sex: All

Ages: 18 to 79 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

1. Subject has end-stage renal disease.
2. Subject has been on regular dialysis treatment for at least 6 months.
3. Subject has autologous vascular access.
4. Subject is offered thrice weekly hemodialysis.
5. Subject is offered 4 hours duration hemodialysis.

Exclusion criteria

1. Infectious disease
2. Poor echocardiographic window that was unsuitable for interpretation

Trial design

Primary purpose: Treatment

Allocation: Non-Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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40 participants in 2 patient groups

High-flux hemodialysis

Experimental group

Description:

High-flux hemodialysis lasting for 4 hours

Treatment:

Other: High-flux hemodialysis

Hemodiafiltration

Active Comparator group

Description:

Hemodiafiltration lasting for 4 hours

Treatment:

Other: Hemodiafiltration